Published evidence

Published Evidence

There are more than 80 peer-reviewed publications reporting studies that involve the use of Vision RT’s technology for SGRT. These span a wide range of indications from brain to breast to sarcoma. In addition, Vision RT supports the SGRT Community, an organization dedicated to education on SGRT by users, for users, which holds biannual meetings and communicates through a dedicated website. Vision RT’s educational funding has been diverted to the SGRT Community since 2016.

Vision RT technology has been widely researched by numerous users including the some of the most respected centers in radiation oncology. Below you can find a list of the journal papers and conference proceedings that detail the use of the technology. Click on the links to view abstracts and full papers where available Use the menu directly below to see the publications listed and organized by treatment site.

Indications

Accuracy

Shun Zhou, et al. (2021). “Development and Longitudinal Analysis of Plan-Based Streamlined Quality Assurance on Multiple Positioning Guidance Systems With Single Phantom Setup”
Frontiers in Oncology Volume 11.
Covington EL, Stanley DN, et al. (2020). “Surface guided imaging during stereotactic radiosurgery with automated delivery.”
Journal of Applied Clinical Medical Physics. 2020 Dec;21(12):90-95.
Wiant D, et al. (2019). “Direct comparison between surface imaging and orthogonal radiographic imaging for SRS localization in phantom.”
J Appl Clin Med Phys 2019; 20:1:137–144
Tang X, et al. (2014). Clinical experience with 3-dimensional surface matching-based deep inspiration breath hold for left-sided breast cancer radiation therapy.
Pract Radiat Oncol 2014;4 (3):e151-158.
Gopan, O., et al. (2012). “Evaluation of the accuracy of a 3D surface imaging system for patient setup in head and neck cancer radiotherapy.”
Int J Radiat Oncol Biol Phys 84(2): 547- 552.

Breast (general)

A. González-Sanchis, L. Brualla-González, C. Fuster-Diana, J. C. Gordo-Partearroyo, T. Piñeiro-Vidal, T. García-Hernandez & J. L. López-Torrecilla (2021). “Surface-guided radiation therapy for breast cancer: more precise positioning” Clinical and Translational Oncology (2021) Published: 11 April 2021
ABSTRACT AVAILABLE
Cravo Sá, A., A. Fermento, D. Neves, S. Ferreira, T. Silva, C. Marques Coelho, A. Vaandering, A. Roma, S. Quaresma and E. Bonnarens (2018). “Radiotherapy setup displacements in breast cancer patients: 3D surface imaging experience.” Reports of Practical Oncology and Radiotherapy 23(1): 61-67.
ABSTRACT AVAILABLE
O’Connor, et al. A Review of the Magnitude of Patient Imaging Shifts in Relation to Departmental Policy Changes. Med Phys 2014;41 (158).
ABSTRACT AVAILABLE
Padilla L, et al. Assessment of interfractional variation of the breast surface following conventional patient positioning for whole-breast radiotherapy. J Appl Clin Med Phys 2014;15 (5):4921.
ACCESS PAPER
Shah AP, et al. Clinical evaluation of interfractional variations for whole breast radiotherapy using 3-dimensional surface imaging. Pract Radiat Oncol 2013;3 (1):16-25.
ACCESS PAPER
Wiant D, et al. The Accuracy of AlignRT Guided Set‐up for Whole Breast and Chestwall Irradiation. Med Phys 2012;39.
ABSTRACT AVAILABLE
Chang AJ, et al. Video surface image guidance for external beam partial breast irradiation. Pract Radiat Oncol 2012;2 (2):97-105.
ABSTRACT AVAILABLE
Deantonio, L., et al. (2011). “Detection of setup uncertainties with 3D surface registration system for conformal radiotherapy of breast cancer.” Rep Pract Oncol Radiother 16(3): 77-81.
ABSTRACT AVAILABLE
Miller DA, et al. Inter-Fraction and Intra-Fraction Breast Motion Localized Using AlignRT for Early Breast Cancer. Int J Radiat Oncol Biol Phys 2008;72 (1):S189-S190.
ABSTRACT AVAILABLE
Gierga, D. P., et al. (2008). “Comparison of target registration errors for multiple image-guided techniques in accelerated partial breast irradiation.” Int J Radiat Oncol Biol Phys 70(4): 1239-1246.
ABSTRACT AVAILABLE
Riboldi, M., et al. (2007). “Quantitative Assessment of Surface Deformation in Accelerated Partial Breast Irradiation.” International Journal of Radiation Oncology • Biology • Physics 69(3): S669.
ABSTRACT AVAILABLE
Schoffel, P. J., et al. (2007). “Accuracy of a commercial optical 3D surface imaging system for realignment of patients for radiotherapy of the thorax.” Phys Med Biol 52(13): 3949-3963.
ABSTRACT AVAILABLE
Bert C, et al. Clinical experience with a 3D surface patient setup system for alignment of partial-breast irradiation patients. Int J Radiat Oncol Biol Phys 2006;64 (4):1265-1274.
ABSTRACT AVAILABLE

DIBH - Left Breast

- - - Ibrahim Duhaini, Bilal Shahine, Youssef Zeidan, Abbas Mkanna, Ahmad Maarouf & Mahmoud Korek (2021). “The effectiveness of the DIBH technique in protecting the heart of radiotherapy breast cancer patients treated at the American University of Beirut Medical Center in Lebanon.” Health and Technology (2021)
      ABSTRACT AVAILABLE
    - Laaksomaa M, et al. Comparison of three differently shaped ROIs in free-breathing breast radiotherapy setup using surface guidance with AlignRT®. (2021) Medica Journals: ISSN: 1507-1367. e-ISSN: 2083-4640
      ACCESS PAPER
    - Hamming, V. C., C. Visser, E. Batin, L. N. McDermott, D. M. Busz, S. Both, J. A. Langendijk and N. M. Sijtsema (2019). “Evaluation of a 3D surface imaging system for deep inspiration breath-hold patient positioning and intra-fraction monitoring.” Radiat. Oncol. 14(1): 125.
      ABSTRACT AVAILABLE
    - Zagar T, et al. Utility of Deep Inspiration Breath Hold for Left-Sided Breast Radiation Therapy in Preventing Early Cardiac Perfusion Defects: A Prospective Study. Int J Radiat Oncol Biol Phys 2017;97 (5):903-909.
      ACCESS PAPER
    - Zagar TM, Cardinale DM Marks LB. Breast cancer therapy-associated cardiovascular disease. Nat Rev Clin Oncol 2016;13 (3):172-184.
      ABSTRACT AVAILABLE
    - Tang X, et al. Dosimetric effect due to the motion during deep inspiration breath hold for left-sided breast cancer radiotherapy. J Appl Clin Med Phys 2015;16 (4):5358.
      ABSTRACT AVAILABLE
    - Rochet N, et al. Deep inspiration breath-hold technique in left-sided breast cancer radiation therapy: Evaluating cardiac contact distance as a predictor of cardiac exposure for patient selection. Pract Radiat Oncol 2015;5 (3):e127-134.
      ABSTRACT AVAILABLE
    - Cheung, Y., et al. (2015). “SU-F-BRB-03: Quantifying Patient Motion During Deep-Inspiration Breath-Hold Using the ABC System with Simultaneous Surface Photogrammetry.” Medical Physics 42(6Part25): 3530-3530.
      ABSTRACT AVAILABLE
    - Tanguturi SK, et al. Prospective assessment of deep inspiration breath-hold using 3-dimensional surface tracking for irradiation of left-sided breast cancer. Pract Radiat Oncol 2015;5 (6):358-365.
      ABSTRACT AVAILABLE
    - Taylor CW, et al. Exposure of the Heart in Breast Cancer Radiation Therapy: A Systematic Review of Heart Doses Published During 2003 to 2013. Int J Radiat Oncol Biol Phys 2015;93 (4):845-853.
      ABSTRACT AVAILABLE
    - Lemanski C, et al. Image-guided radiotherapy for cardiac sparing in patients with left-sided breast cancer. Front Oncol 2014;4:257.
      ACCESS PAPER
    - Rong Y, et al. Improving intra-fractional target position accuracy using a 3d surface surrogate for left breast irradiation using the respiratory-gated deep-inspiration breath-hold technique. PLoS One 2014;9 (5):e97933.
      ACCESS PAPER
    - Darby SC, et al. Risk of Ischemic Heart Disease in Women after Radiotherapy for Breast Cancer. N Engl J Med 2013;368 (11):987-998.
      ACCESS PAPER
    - Gierga DP, et al. A voluntary breath-hold treatment technique for the left breast with unfavorable cardiac anatomy using surface imaging. Int J Radiat Oncol Biol Phys 2012;84 (5):e663-668.
      ABSTRACT AVAILABLE
    - Lyatskaya, Y., et al. (2011). “Validation of Align RT System for Breast Radiation Therapy with Deep Inspiration Breath Hold (DIBH) Technique.” Med Phys 38.
      ABSTRACT AVAILABLE
    - Cervino LI, et al. Using surface imaging and visual coaching to improve the reproducibility and stability of deep-inspiration breath hold for left-breast-cancer radiotherapy. Phys Med Biol 2009;54 (22):6853-6865.
      ACCESS PAPER
    - Harris EE, et al. Late cardiac mortality and morbidity in early-stage breast cancer patients after breast-conservation treatment. J Clin Oncol 2006;24 (25):4100-4106.
      ACCESS PAPER
    - Flampouri S, et al. Position Verification of Breast Treatment with Breath‐Hold Technique Using 3D‐Surface and Fluoroscopic Imaging. Medical Physics 2008;35 (6):2713-2713.
      ABSTRACT AVAILABLE
    - Harris EE. Cardiac mortality and morbidity after breast cancer treatment. Cancer Control 2008;15 (2):120-129.
      ABSTRACT AVAILABLE
    - Clarke M, et al. Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: An overview of the randomised trials. Lancet 2005;366 (9503):2087-2106.
      ACCESS PAPER
    - Marks LB, et al. The incidence and functional consequences of rt-associated cardiac perfusion defects. Int J Radiat Oncol Biol Phys 2005;63 (1):214-223.
      ABSTRACT AVAILABLE

GateCT

Spadea MF, et al. Evaluation and commissioning of a surface based system for respiratory sensing in 4D CT. J Appl Clin Med Phys 2010;12 (1):3288.
ABSTRACT AVAILABLE
Hughes S, et al. Assessment of two novel ventilatory surrogates for use in the delivery of gated/tracked radiotherapy for non-small cell lung cancer. Radiother Oncol 2009;91 (3):336-341.
ABSTRACT AVAILABLE
Noel C, Klein E Moore K. A Surface‐Based Respiratory Surrogate for 4D Imaging. Medical Physics 2008;35 (6):2682-2682.
ABSTRACT AVAILABLE

InBore

Nguyen, Farah et al. Commissioning and performance testing of the first prototype of AlignRT InBore™ a Halcyon™ and Ethos™-dedicated surface guided radiation therapy platform. Phys Med . 2020 Dec;80:159-166. doi: 10.1016/j.ejmp.2020.10.024. Epub 2020 Nov 11
ABSTRACT AVAILABLE
Flores-Martinez, E., L. I. Cervino, T. Pawlicki and G. Y. Kim (2020). “Assessment of the use of different imaging and delivery techniques for cranial treatments on the Halcyon linac.”
ABSTRACT AVAILABLE

Patient Safety

Wiant, D. B., et al. (2016). “A novel method for radiotherapy patient identification using surface imaging.”
J Appl Clin Med Phys 17(2): 271-278.
Manger RP, et al. (2015). “Failure mode and effects analysis and fault tree analysis of surface image guided cranial radiosurgery.”
Med Phys 2015;42 (5):2449-2461.

Pediatric

Mark Sueyoshi, MD et al. Eliminating Daily Shifts, Tattoos, and Skin Marks: Streamlining Isocenter Localization With Treatment Plan Embedded Couch Values for External Beam Radiation Therapy. Practical Radiation Oncology January–February, 2019 Volume 9
ABSTRACT AVAILABLE
Rwigema JM, et al. Palliative radiation therapy for superior vena cava syndrome in metastatic Wilms tumor using 10XFFF and 3D surface imaging to avoid anesthesia in a pediatric patient-a teaching case. Adv Radiat Oncol. 2017 Jan 7;2(1):101-104
ABSTRACT AVAILABLE

Pelvis

Apicella G, et al. (2016). “Three-dimensional surface imaging for detection of intra-fraction setup variations during radiotherapy of pelvic tumors.”
Radiol Med 2016;121 (10):805-810.

Proton

Mutter RW, et al. (2017). “Initial clinical experience of postmastectomy intensity modulated proton therapy in patients with breast expanders with metallic ports.”
Practical Radiation Oncology 2017;7 (4):e243-e252.
Batin E, et al. (2016). “Can surface imaging improve the patient setup for proton postmastectomy chest wall irradiation?”
Pract Radiat Oncol. 6(6):e235-e241.

Sarcoma

Gierga DP, et al. (2014). “Analysis of setup uncertainties for extremity sarcoma patients using surface imaging.”
ABSTRACT AVAILABLE

SBRT / SABR

Naumann, Batista et al. Feasibility of Optical Surface-Guidance for Position Verification and Monitoring of Stereotactic Body Radiotherapy in Deep-Inspiration Breath-Hold. Front Oncol . 2020 Sep 25;10:573279. doi: 10.3389/fonc.2020.573279. eCollection 2020.
ABSTRACT AVAILABLE
Bo Zhao, et al. Surface Guided Motion Management in Glottic Larynx Stereotactic Body Radiation Therapy. September 2020, The Green Journal: Radiotherapy & Oncology
ABSTRACT AVAILABLE
JH Heinzerling, et al. Use of surface‐guided radiation therapy in combination with IGRT for setup and intrafraction motion monitoring during stereotactic body radiation therapy treatments. February 2020, Journal of Applied Clinical Medical Physics
ABSTRACT AVAILABLE
Tanja Alderliesten, et al. 3D surface imaging for monitoring intrafraction motion in frameless stereotactic body radiotherapy of lung cancer. Radiotherapy and Oncology Volume 105, Issue 2, November 2012
ABSTRACT AVAILABLE
H Jin, Z Su. A Comprehensive Evaluation of Real-Time Motion Tracking of a Surface Imaging System for Lung Treatment. Med Phys. 2012 Jun;39(6Part13):3755
ABSTRACT AVAILABLE

SRS

Covington, Stanley, et al. Surface guided imaging during stereotactic radiosurgery with automated delivery. Journal of Applied Clinical Medical Physics. 2020 Dec;21(12):90-95. doi: 10.1002/acm2.13066. Epub 2020 Oct 23
ABSTRACT AVAILABLE
Covington EL, et al. Optical surface guidance for submillimeter monitoring of patient position during frameless stereotactic radiotherapy. Journal of Applied Clinical Medical Physics 2019;20 (6):91-98.
ABSTRACT AVAILABLE
Jursinic, P. (2018). “Comparison of Head Immobilization with a Metal Frame and Two Different Models of Face Masks.” Journal of Cancer and Cure 1(1): 1-7.
ACCESS PAPER
Oliver, J. A., et al. (2017). “Orthogonal image pairs coupled with OSMS for noncoplanar beam angle, intracranial, single-isocenter, SRS treatments with multiple targets on the Varian Edge radiosurgery system.” Adv Radiat Oncol 2(3): 494-502.
ABSTRACT AVAILABLE
Pham NL, et al. Frameless, real-time, surface imaging-guided radiosurgery: Update on clinical outcomes for brain metastases. Translational Cancer Research 2014;3 (4):351-357.
ABSTRACT AVAILABLE
Pan H, et al. Frameless, real-time, surface imaging-guided radiosurgery: Clinical outcomes for brain metastases. Neurosurgery 2012;71 (4):844-851.
ABSTRACT AVAILABLE
Li G, et al. Clinical experience with two frameless stereotactic radiosurgery (fSRS) systems using optical surface imaging for motion monitoring. J Appl Clin Med Phys 2015;16 (4):5416.
ABSTRACT AVAILABLE
Paravati AJ, et al. Initial clinical experience with surface image guided (SIG) radiosurgery for trigeminal neuralgia. Translational Cancer Research 2014;3 (4):333-337
ACCESS PAPER
Baker B Sullivan T. Trigeminal Rhizotomy Performed with Modern Image-guided Linac: Case Report. Cureus 2013;5 (9):e139.
ACCESS PAPER
Li G, et al. Migration from full-head mask to “open-face” mask for immobilization of patients with head and neck cancer. Journal of Applied Medical Physics 2013;14(5):243
ACCESS PAPER
Wen N, et al. Technical Note: Evaluation of the systematic accuracy of a frameless, multiple image modality guided, linear accelerator based stereotactic radiosurgery system. Med Phys 2016;43 (5):2527.
ABSTRACT AVAILABLE
Smith T, et al. Characterization of a High-Definition Optical Patient Surface Tracking System Across Five Installations. Med Phys 2016;43.
ABSTRACT AVAILABLE
Chinsky, B., et al. (2016). “Feasibility of Using a Commercially Available Surface Guided Radiotherapy System with An Open- Face SRS Immobilization System.” Medical Physics 43(6): 3611-3611.
ABSTRACT AVAILABLE
Mancosu P, et al. Accuracy evaluation of the optical surface monitoring system on edge linear accelerator in a phantom study. Med Dosim 2016;41 (2):173-179.
ABSTRACT AVAILABLE
Wen N, et al. Characteristics of a novel treatment system for linear accelerator-based stereotactic radiosurgery. J Appl Clin Med Phys 2015;16 (4):5313.
ABSTRACT AVAILABLE
Lau SK, et al. Single-Isocenter Frameless Volumetric Modulated Arc Radiosurgery for Multiple Intracranial Metastases. Neurosurgery 2015;77 (2):233-240; discussion 240.
ACCESS PAPER
Wiersma RD, et al. Spatial and temporal performance of 3D optical surface imaging for real-time head position tracking. Med Phys 2013;40 (11):111712.
ABSTRACT AVAILABLE
Cervino LI, et al. Initial clinical experience with a frameless and maskless stereotactic radiosurgery treatment. Pract Radiat Oncol 2012;2 (1):54-62.
ABSTRACT AVAILABLE
Li G, et al. Motion monitoring for cranial frameless stereotactic radiosurgery using video-based three-dimensional optical surface imaging. Med Phys 2011;38 (7):3981-3994.
ABSTRACT AVAILABLE
Li G, et al. Optical Surface Imaging for Online Rotation Correction and Real‐Time Motion Monitoring with Threshold Gating for Frameless Cranial Stereotactic Radiosurgery. Med Phys 2011;38.
ABSTRACT AVAILABLE
Cervino LI, et al. Frame-less and mask-less cranial stereotactic radiosurgery: A feasibility study. Phys Med Biol 2010;55 (7):1863-1873.
ABSTRACT AVAILABLE

Other

Rigley, J., P. Robertson and L. Scattergood (2020). “Radiotherapy without tattoos: Could this work?” Radiography (Lond).
ABSTRACT AVAILABLE
Moser, T., M. Creed, R. Walker and G. Meier (2019). “Radiotherapy tattoos: Women’s skin as a carrier of personal memory-What do we cause by tattooing our patients?” Breast J.
ABSTRACT AVAILABLE
Hoisak, J. D. P., et al. (2018). “The Role of Optical Surface Imaging Systems in Radiation Therapy.” Semin Radiat Oncol 28(3): 185-193.
ABSTRACT AVAILABLE
Mharte, V. (2017). “Quality assurance for clinical implementation of an Optical Surface monitoring system.” Journal of Applied Physics 9(6): 15-22.
ACCESS PAPER
Paxton, A. B., et al. (2017). “Evaluation of a surface imaging system’s isocenter calibration methods.” J Appl Clin Med Phys 18(2): 85-91.
ABSTRACT AVAILABLE

Krengli M, et al. Three-dimensional surface and ultrasound imaging for daily IGRT of prostate cancer. Radiat Oncol 2016;11(1):159.
ACCESS PAPER
Zhao B, et al. Feasibility of Open Mask Immobilization with Optical Imaging Guidance (OIG) for H&N Radiotherapy. Med Phys 2016;43.
ABSTRACT AVAILABLE
Li G, et al. Characterization of optical-surface-imaging-based spirometry for respiratory surrogating in radiotherapy. Med Phys 2016;43 (3):1348-1360.
ABSTRACT AVAILABLE
Smith, T., et al. (2016). “Characterization of a High-Definition Optical Patient Surface Tracking System Across Five Installations.” Med Phys 43.
ABSTRACT AVAILABLE
Wiant D, et al. A prospective evaluation of open face masks for head and neck radiation therapy. Pract Radiat Oncol 2016.
ABSTRACT AVAILABLE
Brady, J. L., et al. (2016). “Analysis of Factors Affecting Benefit from Deep Inspiration Breath Hold Technique in Mediastinal Radiation Therapy for Lymphoma.” International Journal of Radiation Oncology • Biology • Physics 96(2): E491.
ABSTRACT AVAILABLE
Brady, J. L., et al. (2016). “Deep inspiration breath hold with ‘AlignRT’ in 3D conformal mediastinal radiotherapy for lymphoma.” Radiotherapy and Oncology 119: S813-S814.
ACCESS PAPER
Mamalui-Hunter M Li Z. Evaluation of the Surface Rendering Patient Localization System for Proton Therapy Facility. Med Phys 2011;2011 (38).
ABSTRACT AVAILABLE
Schoffel PJ, et al. Accuracy of a commercial optical 3d surface imaging system for realignment of patients for radiotherapy of the thorax. Phys Med Biol 2007;52 (13):3949-3963.
ABSTRACT AVAILABLE
Bert C, et al. A phantom evaluation of a stereo-vision surface imaging system for radiotherapy patient setup. Med Phys 2005;32 (9):2753-2762.
ABSTRACT AVAILABLE
Bidmead M, et al. Investigating the correlation between surface and bony anatomy using 3D surface and portal imaging. Radiotherapy and Oncology 2004;73:S233.
ABSTRACT AVAILABLE
Johnson U, et al. Real time 3D surface imaging for the analysis of respiratory motion during radiotherapy. Int J Radiat Oncol Biol Phys;60 (1):S603-S604.
ABSTRACT AVAILABLE

Get in touch to learn more about AlignRT SGRT technology.

Use the form on the right and let us know if you’d like to schedule a demo (virtual or in-person), receive a brochure, get a quote from a member of our sales team, or find out more about our business case and marketing support.