Published evidence

80+ PEER-REVIEWED PUBLICATIONS

There are more than 80 peer-reviewed publications reporting studies that involve the use of Vision RT’s technology for SGRT. These span a wide range of indications from brain to breast to sarcoma.

In addition, Vision RT supports the SGRT Community, an organization dedicated to education on SGRT by users, for users, which holds biannual meetings and communicates through a dedicated website.

Prior to the foundation of The SGRT Community, Vision RT hosted two user meetings, in 2014 and 2015, These meetings gave education and guidance on the best use of AlignRT and other products, largely from existing users.

Vision RT’s educational funding  has been diverted to the SGRT Community since 2016.

Education - Publications

Publications

Vision RT technology has been widely researched by numerous users including the some of the most respected centers in radiation oncology. Below you can find a list of the journal papers and conference proceedings that detail the use of the technology. Click on the links to view abstracts and full papers where available.

Use the menu directly below to see the publications listed and organized by treatment site.

Indications

General Breast

  • A. González-Sanchis, L. Brualla-González, C. Fuster-Diana, J. C. Gordo-Partearroyo, T. Piñeiro-Vidal, T. García-Hernandez & J. L. López-Torrecilla (2021). "Surface-guided radiation therapy for breast cancer: more precise positioning" Clinical and Translational Oncology (2021) Published: 11 April 2021
    ABSTRACT AVAILABLE
  • Cravo Sá, A., A. Fermento, D. Neves, S. Ferreira, T. Silva, C. Marques Coelho, A. Vaandering, A. Roma, S. Quaresma and E. Bonnarens (2018). "Radiotherapy setup displacements in breast cancer patients: 3D surface imaging experience." Reports of Practical Oncology and Radiotherapy 23(1): 61-67.
    ABSTRACT AVAILABLE
  • O'Connor, et al. A Review of the Magnitude of Patient Imaging Shifts in Relation to Departmental Policy Changes. Med Phys 2014;41 (158).
    ABSTRACT AVAILABLE
  • Padilla L, et al. Assessment of interfractional variation of the breast surface following conventional patient positioning for whole-breast radiotherapy. J Appl Clin Med Phys 2014;15 (5):4921.
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  • Shah AP, et al. Clinical evaluation of interfractional variations for whole breast radiotherapy using 3-dimensional surface imaging. Pract Radiat Oncol 2013;3 (1):16-25.
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  • Wiant D, et al. The Accuracy of AlignRT Guided Set‐up for Whole Breast and Chestwall Irradiation. Med Phys 2012;39.
    ABSTRACT AVAILABLE
  • Chang AJ, et al. Video surface image guidance for external beam partial breast irradiation. Pract Radiat Oncol 2012;2 (2):97-105.
    ABSTRACT AVAILABLE

  • Deantonio, L., et al. (2011). “Detection of setup uncertainties with 3D surface registration system for conformal radiotherapy of breast cancer.” Rep Pract Oncol Radiother 16(3): 77-81.
    ABSTRACT AVAILABLE

  • Miller DA, et al. Inter-Fraction and Intra-Fraction Breast Motion Localized Using AlignRT for Early Breast Cancer. Int J Radiat Oncol Biol Phys 2008;72 (1):S189-S190.
    ABSTRACT AVAILABLE

  • Gierga, D. P., et al. (2008). “Comparison of target registration errors for multiple image-guided techniques in accelerated partial breast irradiation.” Int J Radiat Oncol Biol Phys 70(4): 1239-1246.
    ABSTRACT AVAILABLE

  • Riboldi, M., et al. (2007). “Quantitative Assessment of Surface Deformation in Accelerated Partial Breast Irradiation.” International Journal of Radiation Oncology • Biology • Physics 69(3): S669.
    ABSTRACT AVAILABLE

  • Schoffel, P. J., et al. (2007). “Accuracy of a commercial optical 3D surface imaging system for realignment of patients for radiotherapy of the thorax.” Phys Med Biol 52(13): 3949-3963.
    ABSTRACT AVAILABLE

  • Bert C, et al. Clinical experience with a 3D surface patient setup system for alignment of partial-breast irradiation patients. Int J Radiat Oncol Biol Phys 2006;64 (4):1265-1274.
    ABSTRACT AVAILABLE

Left Breast (Deep Inspiration Breath Hold)

        • Hamming, V. C., C. Visser, E. Batin, L. N. McDermott, D. M. Busz, S. Both, J. A. Langendijk and N. M. Sijtsema (2019). "Evaluation of a 3D surface imaging system for deep inspiration breath-hold patient positioning and intra-fraction monitoring." Radiat. Oncol. 14(1): 125.
          ABSTRACT AVAILABLE
        • Zagar T, et al. Utility of Deep Inspiration Breath Hold for Left-Sided Breast Radiation Therapy in Preventing Early Cardiac Perfusion Defects: A Prospective Study. Int J Radiat Oncol Biol Phys 2017;97 (5):903-909.
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        • Tang X, et al. Dosimetric effect due to the motion during deep inspiration breath hold for left-sided breast cancer radiotherapy. J Appl Clin Med Phys 2015;16 (4):5358.
          ABSTRACT AVAILABLE
        • Rochet N, et al. Deep inspiration breath-hold technique in left-sided breast cancer radiation therapy: Evaluating cardiac contact distance as a predictor of cardiac exposure for patient selection. Pract Radiat Oncol 2015;5 (3):e127-134.
          ABSTRACT AVAILABLE

        • Cheung, Y., et al. (2015). “SU-F-BRB-03: Quantifying Patient Motion During Deep-Inspiration Breath-Hold Using the ABC System with Simultaneous Surface Photogrammetry.” Medical Physics 42(6Part25): 3530-3530.
          ABSTRACT AVAILABLE

        • Tanguturi SK, et al. Prospective assessment of deep inspiration breath-hold using 3-dimensional surface tracking for irradiation of left-sided breast cancer. Pract Radiat Oncol 2015;5 (6):358-365.
          ABSTRACT AVAILABLE
        • Rong Y, et al. Improving intra-fractional target position accuracy using a 3d surface surrogate for left breast irradiation using the respiratory-gated deep-inspiration breath-hold technique. PLoS One 2014;9 (5):e97933.
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        • Tang X, et al. Clinical experience with 3-dimensional surface matching-based deep inspiration breath hold for left-sided breast cancer radiation therapy. Pract Radiat Oncol 2014;4 (3):e151-158.
          ABSTRACT AVAILABLE
        • Gierga DP, et al. A voluntary breath-hold treatment technique for the left breast with unfavorable cardiac anatomy using surface imaging. Int J Radiat Oncol Biol Phys 2012;84 (5):e663-668.
          ABSTRACT AVAILABLE
        • Cervino LI, et al. Using surface imaging and visual coaching to improve the reproducibility and stability of deep-inspiration breath hold for left-breast-cancer radiotherapy. Phys Med Biol 2009;54 (22):6853-6865.
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        • Flampouri S, et al. Position Verification of Breast Treatment with Breath‐Hold Technique Using 3D‐Surface and Fluoroscopic Imaging. Medical Physics 2008;35 (6):2713-2713.
          ABSTRACT AVAILABLE
        • Zagar TM, Cardinale DM Marks LB. Breast cancer therapy-associated cardiovascular disease. Nat Rev Clin Oncol 2016;13 (3):172-184.
          ABSTRACT AVAILABLE
        • Taylor CW, et al. Exposure of the Heart in Breast Cancer Radiation Therapy: A Systematic Review of Heart Doses Published During 2003 to 2013. Int J Radiat Oncol Biol Phys 2015;93 (4):845-853.
          ABSTRACT AVAILABLE
        • Lemanski C, et al. Image-guided radiotherapy for cardiac sparing in patients with left-sided breast cancer. Front Oncol 2014;4:257.
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        • Darby SC, et al. Risk of Ischemic Heart Disease in Women after Radiotherapy for Breast Cancer. N Engl J Med 2013;368 (11):987-998.
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        • Lyatskaya, Y., et al. (2011). “Validation of Align RT System for Breast Radiation Therapy with Deep Inspiration Breath Hold (DIBH) Technique.” Med Phys 38.
          ABSTRACT AVAILABLE

        • Harris EE, et al. Late cardiac mortality and morbidity in early-stage breast cancer patients after breast-conservation treatment. J Clin Oncol 2006;24 (25):4100-4106.
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        • Harris EE. Cardiac mortality and morbidity after breast cancer treatment. Cancer Control 2008;15 (2):120-129.
          ABSTRACT AVAILABLE
        • Clarke M, et al. Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: An overview of the randomised trials. Lancet 2005;366 (9503):2087-2106.
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        • Marks LB, et al. The incidence and functional consequences of rt-associated cardiac perfusion defects. Int J Radiat Oncol Biol Phys 2005;63 (1):214-223.
          ABSTRACT AVAILABLE
        • Laaksomaa M, et al. Comparison of three differently shaped ROIs in free-breathing breast radiotherapy setup using surface guidance with AlignRT®.  Medica Journals: ISSN: 1507-1367. e-ISSN: 2083-4640
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SRS

  • Covington, Stanley, et al. Surface guided imaging during stereotactic radiosurgery with automated delivery. Journal of Applied Clinical Medical Physics. 2020 Dec;21(12):90-95. doi: 10.1002/acm2.13066. Epub 2020 Oct 23
    ABSTRACT AVAILABLE
  • Covington EL, et al. Optical surface guidance for submillimeter monitoring of patient position during frameless stereotactic radiotherapy. Journal of Applied Clinical Medical Physics 2019;20 (6):91-98.
    ABSTRACT AVAILABLE
  • Jursinic, P. (2018). "Comparison of Head Immobilization with a Metal Frame and Two Different Models of Face Masks." Journal of Cancer and Cure  1(1): 1-7.
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  • Oliver, J. A., et al. (2017). “Orthogonal image pairs coupled with OSMS for noncoplanar beam angle, intracranial, single-isocenter, SRS treatments with multiple targets on the Varian Edge radiosurgery system.” Adv Radiat Oncol 2(3): 494-502.
    ABSTRACT AVAILABLE

  • Pham NL, et al. Frameless, real-time, surface imaging-guided radiosurgery: Update on clinical outcomes for brain metastases. Translational Cancer Research 2014;3 (4):351-357.
    ABSTRACT AVAILABLE
  • Pan H, et al. Frameless, real-time, surface imaging-guided radiosurgery: Clinical outcomes for brain metastases. Neurosurgery 2012;71 (4):844-851.
    ABSTRACT AVAILABLE
  • Li G, et al. Clinical experience with two frameless stereotactic radiosurgery (fSRS) systems using optical surface imaging for motion monitoring. J Appl Clin Med Phys 2015;16 (4):5416.
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  • Paravati AJ, et al. Initial clinical experience with surface image guided (SIG) radiosurgery for trigeminal neuralgia. Translational Cancer Research 2014;3 (4):333-337.
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  • Baker B Sullivan T. Trigeminal Rhizotomy Performed with Modern Image-guided Linac: Case Report. Cureus 2013;5 (9):e139.
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  • Li G, et al. Migration from full-head mask to “open-face” mask for immobilization of patients with head and neck cancer. Journal of Applied Medical Physics 2013;14(5):243
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  • Wen N, et al. Technical Note: Evaluation of the systematic accuracy of a frameless, multiple image modality guided, linear accelerator based stereotactic radiosurgery system. Med Phys 2016;43 (5):2527.
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  • Smith T, et al. Characterization of a High-Definition Optical Patient Surface Tracking System Across Five Installations. Med Phys 2016;43.
    ABSTRACT AVAILABLE

  • Chinsky, B., et al. (2016). “Feasibility of Using a Commercially Available Surface Guided Radiotherapy System with An Open- Face SRS Immobilization System.” Medical Physics 43(6): 3611-3611.
    ABSTRACT AVAILABLE

  • Mancosu P, et al. Accuracy evaluation of the optical surface monitoring system on edge linear accelerator in a phantom study. Med Dosim 2016;41 (2):173-179.
    ABSTRACT AVAILABLE
  • Manger RP, et al. Failure mode and effects analysis and fault tree analysis of surface image guided cranial radiosurgery. Med Phys 2015;42 (5):2449-2461.
    ABSTRACT AVAILABLE
  • Wen N, et al. Characteristics of a novel treatment system for linear accelerator-based stereotactic radiosurgery. J Appl Clin Med Phys 2015;16 (4):5313.
    ABSTRACT AVAILABLE
  • Lau SK, et al. Single-Isocenter Frameless Volumetric Modulated Arc Radiosurgery for Multiple Intracranial Metastases. Neurosurgery 2015;77 (2):233-240; discussion 240.
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  • Wiersma RD, et al. Spatial and temporal performance of 3D optical surface imaging for real-time head position tracking. Med Phys 2013;40 (11):111712.
    ABSTRACT AVAILABLE
  • Cervino LI, et al. Initial clinical experience with a frameless and maskless stereotactic radiosurgery treatment. Pract Radiat Oncol 2012;2 (1):54-62.
    ABSTRACT AVAILABLE
  • Li G, et al. Motion monitoring for cranial frameless stereotactic radiosurgery using video-based three-dimensional optical surface imaging. Med Phys 2011;38 (7):3981-3994.
    ABSTRACT AVAILABLE
  • Li G, et al. Optical Surface Imaging for Online Rotation Correction and Real‐Time Motion Monitoring with Threshold Gating for Frameless Cranial Stereotactic Radiosurgery. Med Phys 2011;38.
    ABSTRACT AVAILABLE
  • Cervino LI, et al. Frame-less and mask-less cranial stereotactic radiosurgery: A feasibility study. Phys Med Biol 2010;55 (7):1863-1873.
    ABSTRACT AVAILABLE

GateCT

  • Spadea MF, et al. Evaluation and commissioning of a surface based system for respiratory sensing in 4D CT. J Appl Clin Med Phys 2010;12 (1):3288.
    ABSTRACT AVAILABLE
  • Hughes S, et al. Assessment of two novel ventilatory surrogates for use in the delivery of gated/tracked radiotherapy for non-small cell lung cancer. Radiother Oncol 2009;91 (3):336-341.
    ABSTRACT AVAILABLE
  • Noel C, Klein E Moore K. A Surface‐Based Respiratory Surrogate for 4D Imaging. Medical Physics 2008;35 (6):2682-2682.
    ABSTRACT AVAILABLE

SBRT / SABR

  • Naumann, Batista et al. Feasibility of Optical Surface-Guidance for Position Verification and Monitoring of Stereotactic Body Radiotherapy in Deep-Inspiration Breath-Hold. Front Oncol . 2020 Sep 25;10:573279. doi: 10.3389/fonc.2020.573279. eCollection 2020.
    ABSTRACT AVAILABLE
  • Bo Zhao, et al. Surface Guided Motion Management in Glottic Larynx Stereotactic Body Radiation Therapy.  September 2020, The Green Journal: Radiotherapy & Oncology
    ABSTRACT AVAILABLE
  • JH Heinzerling, et al. Use of surface‐guided radiation therapy in combination with IGRT for setup and intrafraction motion monitoring during stereotactic body radiation therapy treatments. February 2020, Journal of Applied Clinical Medical Physics
    ABSTRACT AVAILABLE
  • Tanja Alderliesten, et al. 3D surface imaging for monitoring intrafraction motion in frameless stereotactic body radiotherapy of lung cancer. Radiotherapy and Oncology Volume 105, Issue 2, November 2012
    ABSTRACT AVAILABLE
  • H Jin, Z Su. A Comprehensive Evaluation of Real-Time Motion Tracking of a Surface Imaging System for Lung Treatment. Med Phys. 2012 Jun;39(6Part13):3755
    ABSTRACT AVAILABLE

Pediatric

  • Mark Sueyoshi, MD et al. Eliminating Daily Shifts, Tattoos, and Skin Marks: Streamlining Isocenter Localization With Treatment Plan Embedded Couch Values for External Beam Radiation Therapy. Practical Radiation Oncology January–February, 2019 Volume 9
    ABSTRACT AVAILABLE
  • Rwigema JM, et al. Palliative radiation therapy for superior vena cava syndrome in metastatic Wilms tumor using 10XFFF and 3D surface imaging to avoid anesthesia in a pediatric patient-a teaching case. Adv Radiat Oncol. 2017 Jan 7;2(1):101-104
    ABSTRACT AVAILABLE

InBore

  • Nguyen, Farah et al.  Commissioning and performance testing of the first prototype of AlignRT InBore™ a Halcyon™ and Ethos™-dedicated surface guided radiation therapy platform. Phys Med . 2020 Dec;80:159-166. doi: 10.1016/j.ejmp.2020.10.024. Epub 2020 Nov 11
    ABSTRACT AVAILABLE

Other

  • Rigley, J., P. Robertson and L. Scattergood (2020). "Radiotherapy without tattoos: Could this work?" Radiography (Lond).
    ABSTRACT AVAILABLE

  • Moser, T., M. Creed, R. Walker and G. Meier (2019). "Radiotherapy tattoos: Women's skin as a carrier of personal memory-What do we cause by tattooing our patients?" Breast J.
    ABSTRACT AVAILABLE

  • Mharte, V. (2017). "Quality assurance for clinical implementation of an Optical Surface monitoring system." Journal of Applied Physics 9(6): 15-22.
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  • Mutter RW, et al. (2017). Initial clinical experience of postmastectomy intensity modulated proton therapy in patients with breast expanders with metallic ports. Practical Radiation Oncology 2017;7 (4):e243-e252.
    ABSTRACT AVAILABLE

  • Hoisak, J. D. P., et al. (2018). “The Role of Optical Surface Imaging Systems in Radiation Therapy.” Semin Radiat Oncol 28(3): 185-193.
    ABSTRACT AVAILABLE

  • Paxton, A. B., et al. (2017). “Evaluation of a surface imaging system’s isocenter calibration methods.” J Appl Clin Med Phys 18(2): 85-91.
    ABSTRACT AVAILABLE

  • Flores-Martinez, E., L. I. Cervino, T. Pawlicki and G. Y. Kim (2020). "Assessment of the use of different imaging and delivery techniques for cranial treatments on the Halcyon linac." J Appl Clin Med Phys 21(1): 53-61.
    ABSTRACT AVAILABLE
  • Krengli M, et al. Three-dimensional surface and ultrasound imaging for daily IGRT of prostate cancer. Radiat Oncol 2016;11(1):159.
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  • Zhao B, et al. Feasibility of Open Mask Immobilization with Optical Imaging Guidance (OIG) for H&N Radiotherapy. Med Phys 2016;43.
    ABSTRACT AVAILABLE
  • Li G, et al. Characterization of optical-surface-imaging-based spirometry for respiratory surrogating in radiotherapy. Med Phys 2016;43 (3):1348-1360.
    ABSTRACT AVAILABLE

  • Smith, T., et al. (2016). “Characterization of a High-Definition Optical Patient Surface Tracking System Across Five Installations.” Med Phys 43.
    ABSTRACT AVAILABLE

  • Wiant D, et al. A prospective evaluation of open face masks for head and neck radiation therapy. Pract Radiat Oncol 2016.
    ABSTRACT AVAILABLE
  • Batin E, et al. Can surface imaging improve the patient setup for proton postmastectomy chest wall irradiation? Pract Radiat Oncol 2016.
    ABSTRACT AVAILABLE
  • Apicella G, et al. Three-dimensional surface imaging for detection of intra-fraction setup variations during radiotherapy of pelvic tumors. Radiol Med 2016;121 (10):805-810.
    ABSTRACT AVAILABLE
  • Gierga DP, et al. Analysis of setup uncertainties for extremity sarcoma patients using surface imaging. Pract Radiat Oncol 2014;4 (4):261-266.
    ABSTRACT AVAILABLE
  • Mamalui-Hunter M Li Z. Evaluation of the Surface Rendering Patient Localization System for Proton Therapy Facility. Med Phys 2011;2011 (38).
    ABSTRACT AVAILABLE
  • Bert C, et al. A phantom evaluation of a stereo-vision surface imaging system for radiotherapy patient setup. Med Phys 2005;32 (9):2753-2762.
    ABSTRACT AVAILABLE

  • Brady, J. L., et al. (2016). “Analysis of Factors Affecting Benefit from Deep Inspiration Breath Hold Technique in Mediastinal Radiation Therapy for Lymphoma.” International Journal of Radiation Oncology • Biology • Physics 96(2): E491.
    ABSTRACT AVAILABLE

  • Brady, J. L., et al. (2016). “Deep inspiration breath hold with ‘AlignRT’ in 3D conformal mediastinal radiotherapy for lymphoma.” Radiotherapy and Oncology 119: S813-S814.
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  • Bidmead M, et al. Investigating the correlation between surface and bony anatomy using 3D surface and portal imaging. Radiotherapy and Oncology 2004;73:S233.
    ABSTRACT AVAILABLE
  • Schoffel PJ, et al. Accuracy of a commercial optical 3d surface imaging system for realignment of patients for radiotherapy of the thorax. Phys Med Biol 2007;52 (13):3949-3963.
    ABSTRACT AVAILABLE

  • Gopan, O., et al. (2012). “Evaluation of the accuracy of a 3D surface imaging system for patient setup in head and neck cancer radiotherapy.” Int J Radiat Oncol Biol Phys 84(2): 547- 552.
    ABSTRACT AVAILABLE

  • Johnson U, et al. Real time 3D surface imaging for the analysis of respiratory motion during radiotherapy. Int J Radiat Oncol Biol Phys;60 (1):S603-S604.
    ABSTRACT AVAILABLE